Tyrone Smith was the founder of Unity, Inc., an early African-American HIV/AIDS education and services agency in Philadelphia which included Unity Housing in West Philadelphia. He also served on the boards of We the People and the William J. Craig Foundation. Smith was a community advisor to the Penn Medicine’s Center for AIDS Research and was Board President of The Colours Organization, Inc., whose mission focuses on enriching the lives of LGBT communities of color by providing wellness services and holding events to unite and strengthen the community.